ABSTRACT
A tricuríase é uma doença parasitária causada pelo Trichuris trichiura, com importante impacto universal. No presente artigo é apresentada uma revisão sobre os aspectos mais relevantes da tricuríase.
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Middle Aged , Trichuriasis/diagnosis , Trichuriasis/etiology , Trichuriasis/parasitology , Trichuriasis/pathology , Trichuriasis/prevention & control , Trichuriasis/therapy , Child Welfare , Health EducationABSTRACT
Most patients with trichuriasis have light worm burdens. Data regarding the inflammatory response to Trichuris worms in the colon of lightly infected persons are scant. Nine patients whose Trichuris infection was found by colonoscopy had biopsies taken from a site adjacent to visible worms and from a second site some 20 cm distally. The biopsies were studied by routine and immunohistochemical methods. None of the biopsies showed mucosal ulceration, significant congestion, fibrosis, gland distortion or goblet cell mucin depletion. There was no difference between worm and worm-free sites in terms of edema, lymphoid follicles or epithelial slough. Worm sites had higher numbers of eosinophils, neutrophils and total inflammatory cells and lower numbers of plasma cells. However there was no difference in lymphocyte, mast cell, and B- and T-cell counts between the two sites. This suggests that the T. trichiura worm incites a local inflammatory response involving eosinophils and neutrophils, even when the colon has only a light burden of worms.
Subject(s)
Adult , Aged , Biopsy , Colon/pathology , Colonoscopy , Female , Humans , Malaysia , Male , Middle Aged , Trichuriasis/pathologyABSTRACT
El tricocéfalo Trichuris trichiura tiene una distribución cosmopolita; sin embargo, en México es muy prevalente en los estados tropicales como Guerrero, Chiapas, Oaxaca, Campeche, Tabasco, Yucatán, Veracruz y Nayarit. En los focos endémicos los niños pequeños de las familias pobres, desarrollan a menudo infecciones masivas, principalmente por comer tierra contaminada de los corrales, aunque la prevalencia más alta de tricuriasis sintomática ocurre entre los preescolares y escolares. Las infecciones por tricocéfalos se pueden demostrar al encontrarse los huevecillos característicos en las heces, o cuando los gusanos adultos se pueden ver pegados al recto prolapsado o en la sigmoidoscopia. La tricuriasis puede ser controlable solo manteniendo un alto estándar de sanidad ambiental, pero actualmente es factible el tratamiento colectivo, porque el mebendazol y el albendazol son eficaces y seguros. El oxantel es otra droga atóxica y barata, que ofrece ser útil para los tratamientos masivos